Dr Marcus Gallagher-Jones
Marcus received his BSc in Biochemistry from Durham University and his PhD in Biophysics from the University of Liverpool. For his postdoctoral work he moved to UCLA where he worked in both the department of Physics and the department of Chemistry and Biochemistry. During his time at UCLA he applied soft X-ray ptychography to the study of cellular interactions with nanoparticles, used MicroED to interrogate the structures of peptides and small proteins from sub-micron sized crystals, and applied cryo-4DSTEM to study the overall architecture of peptide/protein nanocrystals.
At the Franklin, Marcus is continuing to develop MicroED, looking to make use of energy-filtered diffraction to study the roles of metal ions in biology. He is also continuing to use cryo-4DSTEM techniques such as nanobeam diffraction mapping and ptychography to study higher-order biological assemblies.
Aberration-corrected transmission electron microscope
Ruska is an aberration-corrected transmission electron microscope (TEM) used to explore novel methods to study radiation sensitive specimens such as biological materials that have been cryogenically preserved or encapsulated in liquid for dynamic observations.
MicroED
MicroED is an emerging technology that exploits the strong interaction of electrons to reveal the structures of molecules from vanishingly small crystals.
Electron Detector Development
Atomic resolution imaging with electrons causes sample damage. The information per unit of damage is dependent on sample thickness and beam energy.