Fast Spectroscopy
We study how light can trigger changes in biomolecules to activate biological functions using different spectroscopic methods.
We focus on synthetic modifications of biomolecules and the mechanisms of light-triggered proteins. These studies help us understand how to control biomolecular functions with precision, opening new possibilities in biomolecular research.
We utilize a state-of-the-art transient absorption spectrometer to investigate ultrafast dynamics, enabling us to capture time-resolved processes occurring within a window of 200 femtoseconds to 10 nanoseconds. For excitation, we employ an optical parametric amplifier (OPA) capable of delivering pump pulses tunable across a wide spectral range of 350 to 2400 nm. Our probe beam complements this by covering the spectral region from 350 to 1600 nm, allowing comprehensive coverage of light-induced processes. This advanced setup is instrumental in exploring biomolecular modifications driven by light, offering deep insights into the mechanisms and dynamics underlying such transformations. We complement our transient studies with additional spectroscopic techniques available at the Central Laser Facility and the Diamond Light Source. Furthermore, to enhance the scope of our research, we are integrating synthesis platforms with the transient absorption system. This synchronization will enable high-throughput screening of photochemical reactions, significantly accelerating the discovery and optimization of light-driven molecular processes.
In collaboration with other teams at the Franklin, we are also developing optical and mass imaging platforms. These tools are designed to advance disease marker detection and identification.
Collaboration
We are always open to collaborations with those who share our deep interest in light-triggered chemistry in biological systems. We warmly welcome collaborative opportunities to study light-triggered biology.
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