New tools for analysis of new drug modalities: Native ambient mass spectrometry of novel large molecule drugs
Native ambient mass spectrometry (NAMS) is an emerging field that enables label-free characterization of proteins and their complexes directly from their biological environment.
NAMS has the potential to be an enormously powerful tool for drug discovery as it offers the possibility to obtain structural information on a protein-drug complex, together with its spatial distribution via mass spectrometry imaging (MSI) directly from the tissue itself. This project will further develop and apply the unique instrumentation available at the Franklin for in situ analysis of protein-drug interactions focusing on novel protein drug modalities, including radioconjugates.
