Electron Diffraction Based Methods of Structure Elucidation
X-ray crystallography has been for many years the primary method of revealing the atomic coordinates of biological and small organic molecules.
However, there are molecules that have remained resistant to structure determination due to their inability to form crystals larger than 1 micron. Electrons, by virtue of their greater scattering cross section, can unlock the potential of nanocrystals. We are developing tools for structural elucidation from nanocrystals of proteins and organic small molecules using a variety of electron diffraction methods.
