Defining how Cells and Pathogens Interact
An essential requirement for rational development of antimicrobial drugs for the treatment of bacterial and viral infections is the understanding of mechanisms that drive pathogenesis.
We aim to develop innovative strategies for incorporation of probes and labels (through biological or chemical approaches) that will be enable us to image and map molecular details of host pathogen interactions across different length scales in near-native environments ( e.g. cells ,tissue). This will be achieved using a combination of technologies developed by the Rosalind Franklin Institute such as cryo-ET, Ptychography, optical imaging, Mass spectrometry, NMR, AI. Our goal is to unravel events that influence early stages of infection and mechanism of persistence, with the aim of identifying potential antimicrobial targets and new strategies for pathogen detections and therapeutic interventions.
Scientists associated
Dr Lucile Moynie
Associate Investigator
Associate Professor Shabaz Mohammed
Head of Mechanistic Proteomics
Professor Ben Davis
Challenge Lead
Dr Maud Dumoux
Deputy Challenge Lead, Quantitative Biology Across Scales
Professor Ray Owens
Challenge Lead
Dr Liang Wu
Wellcome Trust Sir Henry Dale fellow
Dr Chen Huang
Senior Staff Scientist
Dr Alexandre Paschoal
Group Leader (Investigator)
Dr Felicia Green
Associate Investigator
Professor Andrew Baldwin
Head of Biomolecular NMR
Dr Michele Darrow
Challenge Lead