Cryogenic electron imaging for investigating the molecular sociology within cells and tissues
Electron imaging under cryogenic conditions allows cells and tissues to be imaged on multiple scales, with pristine preservation of fine molecular detail.
Tools to bridge the gap between structure and cellular dysfunction are needed. We are building approaches to determine molecular structures within the wider context of intact cells and, more importantly, tissues, including novel methods for labelling and targeting molecules in the cell. We focus our approach on several biological areas, including neuroscience, host-pathogen interactions, and glycobiology.
Scientists associated
Dr Maud Dumoux
Deputy Challenge Lead, Quantitative Biology Across Scales
Dr Liang Wu
Wellcome Trust Sir Henry Dale fellow
Dr Michael Grange
Tomography Group Leader
Professor Ray Owens
Challenge Lead
Dr Casper Berger
Senior Application Expert
Dr Michele Darrow
Challenge Lead
Dr Mark Basham
Challenge Lead