Coincidental Lattice Light Sheet Microscopy and Structured Illumination Microscopy for quantitative tissue, cellular and biomolecular dynamics
Quantitative correlative imaging is now mission critical in biomedical sciences.
A key development is the UK’s first Biophotonic Correlative Optical Platform (BioCOP) at the RFI, based on Lattice Light Sheet Microscopy (LLSM). This advanced technology offers 100-fold faster imaging than standard microscopes and 3D fluorescence imaging with diffraction-limited spatial resolution in up to seven colours. The projects aim to revolutionize live-cell imaging by developing imaging and analysis pipelines such as Structured Illumination Microscopy and combine LLSM with Fluorescence Correlation Spectroscopy (FCS). The BioCOP will enable high throughput, multiplexed, and deep tissue imaging, advancing the study of biomolecular dynamics in membranes and solutions.
