Chemical Biology
Cells rely on a range of biomolecules to maintain function and respond to change.
There are highly complex interdependent relationships between these biomolecules that are also incredibly dynamic. Key nodes or certain biomoelcules are key in specific circumstances. Monitoring or modulating the status (of e,g. a kinase) allows substantial insight or remedy of cellular behaviour (i.e. disease), respectively. Our groups develop a range of molecular biological and chemical approaches to monitor and/or modulate a protein’s structure in cellulo or in vivo. Often, approaches are developed to allow heightened detection within the cell/tissue and its partners by techniques such as Cryo-ET/EM, PET, EPR, NMR, Raman and Mass Spectrometry.
Scientists associated
Professor Ben Davis
Challenge Lead
Dr Lucile Moynie
Associate Investigator
Dr Liang Wu
Wellcome Trust Sir Henry Dale fellow
Dr Adeline Poh
Visiting Associate Investigator
Dr Karina Pombo-Garcia
Group Leader
Associate Professor Shabaz Mohammed
Head of Mechanistic Proteomics
Professor Andrew Baldwin
Head of Biomolecular NMR