Microscopy
Structural Glycobiology
Complex carbohydrate molecules are essential for life. These diverse structures are found on every human cell and participate in a huge range of structural and signalling functions within cells, and between cells and the extracellular matrix.
Electron Detector Development
Atomic resolution imaging with electrons causes sample damage. The information per unit of damage is dependent on sample thickness and beam energy.
Stimulated Emission Depletion Microscopy (STED)
We are from investigating how cells communicate with one another, to understand more complex structures such as those found in organoid and tissue formation.
Cellular Compartmentalisation and Condensate Formation from Biology to Physical-Chemistry
The cellular environment is a complex mix of biomolecules that organize themselves to carry out vital physiological cell processes.
Cell-Cell Interactions
One of the biggest challenges in contemporary biology is to understand how cells integrate chemical and physical signals to drive self-assembly, which underpins the formation of complex architectures such as tissues and organs.
Coincidental Lattice Light Sheet Microscopy and Structured Illumination Microscopy for quantitative tissue, cellular and biomolecular dynamics
Quantitative correlative imaging is now mission critical in biomedical sciences.
Multidimensional Imaging of Molecular Structures
Our aim: To develop new technologies to see the molecules of life and their dynamics with unprecedented detail.