Mass spectrometry
Structural Elucidation
Mass Spectrometry (MS) is an extremely sensitive analytical tool that provides accurate mass-related data for molecules ranging from small metabolites to protein complexes.
Subcellular Imaging
Next generation MS instrumentation will enable rapid molecular mapping of cells in tissue enabling elucidation of the chemistry behind biological mechanisms.
Biochemical Microscopy for imaging across Molecular Scales
Developing a transformative cryogenic 3D biochemical microscope, harnessing the power of high-resolution electron microscopy and mass spectrometry imaging
3D Protein Atlas of Brain
Native ambient mass spectrometry (NAMS) is an emerging technology which offers unprecedented potential for integration of spatial and structural biology – it promises major advances in molecular pathology and drug discovery.
Mechanistic Proteomics
Proteins are the workhorses of living cells. Proteins operate in a highly dynamic environment interacting with other proteins and other types of molecules including sugars, lipids and nucleic acids.
High Resolution imaging with secondary ion mass spectrometry (SIMS)
Secondary Ion Mass Spectrometry (SIMS) is a highly sensitive analytical technique offering detailed chemical composition analysis in 3D space with subcellular resolution.
Trapped ion mobility (TIMS) time of flight (TOF) mass spectrometry
A cutting-edge commercial Bruker mass spectrometry (MS) instrument, coupling high sensitivity, high resolution, rapid time of flight (TOF) mass analysis to high resolution trapped ion mobility spectrometry (TIMS) enabling structural elucidation.
Native ambient mass spectrometry
Native ambient mass spectrometry (NAMS) combines spatial and structural biology by enabling untargeted label-free interrogation of proteins in their functional form directly from their physiological environment.
Defining how Cells and Pathogens Interact
An essential requirement for rational development of antimicrobial drugs for the treatment of bacterial and viral infections is the understanding of mechanisms that drive pathogenesis.
Imaging neurodegeneration using mass spectrometry to understand the mechanisms of disease in the brain
Given the high complexity and heterogeneity of the cells in the brain, spatial information of molecular organisation is essential for the understanding of and insights into cellular processes.