Cryo-EM
Structural Glycobiology
Complex carbohydrate molecules are essential for life. These diverse structures are found on every human cell and participate in a huge range of structural and signalling functions within cells, and between cells and the extracellular matrix.
Electron Detector Development
Atomic resolution imaging with electrons causes sample damage. The information per unit of damage is dependent on sample thickness and beam energy.
Aberration-corrected transmission electron microscope
Ruska is an aberration-corrected transmission electron microscope (TEM) used to explore novel methods to study radiation sensitive specimens such as biological materials that have been cryogenically preserved or encapsulated in liquid for dynamic observations.
Large Volume Tomography
High resolution large volume tomography with electron microscopy has the potential to transform our understanding of life, by linking the atomic and molecular structure of protein complexes in their biological context – the cell.
Cryogenic Electron Microscope (cryoARM)
Crewe is a first-generation cryogenic electron microscope based on JEOL’s atomic resolution microscope platform (ARM).
Chromatic Aberration-Corrected Electron Microscope
Knoll, the first chromatic aberration-corrected electron microscope in the UK, will push the current resolution limits for biological samples by correcting energy variations in the electron beam. This allows detailed imaging of thicker and liquid samples, benefiting biology by enabling…
Defining how Cells and Pathogens Interact
An essential requirement for rational development of antimicrobial drugs for the treatment of bacterial and viral infections is the understanding of mechanisms that drive pathogenesis.
Electron Ptychography and Phase Retrieval in Electron Microscopy
Cryogenic electron ptychography uses coherent diffractive imaging techniques with computational iterative phase retrieval algorithms.
Damage Reduction using Alternative Scanning Methods in Electron Microscopy
The main limitation to perform localized analysis in electron microscopy is radiation damage.
Cryogenic electron imaging for investigating the molecular sociology within cells and tissues
Electron imaging under cryogenic conditions allows cells and tissues to be imaged on multiple scales, with pristine preservation of fine molecular detail.